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Clinical Trials/NCT06620900
NCT06620900
Not yet recruiting
Not Applicable

Expanding Access to mTBI Treatment for Veterans and Service Members With Co-occurring Substance Use

Shepherd Center, Atlanta GA1 site in 1 country360 target enrollmentFebruary 2025

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Concussion, Mild Traumatic Brain Injury
Sponsor
Shepherd Center, Atlanta GA
Enrollment
360
Locations
1
Primary Endpoint
Neurobehavioral Symptom Inventory (NSI)
Status
Not yet recruiting
Last Updated
last year

Overview

Brief Summary

The purpose of this research is to determine whether military veterans and service members with mild traumatic brain injury with and without co-occurring substance use can complete and benefit from integrated interdisciplinary care individualized to their symptoms, goals, and needs.

Participants will complete surveys about substance use and other symptoms at the beginning and end of treatment in an intensive outpatient program and 6 months after discharge.

Detailed Description

This pragmatic clinical trial will (1) assess treatment retention and treatment outcomes at the completion of interdisciplinary intensive outpatient program (IOP) and at a 6-month follow-up comparing service members and veterans (SM/Vs) with mild traumatic brain injury (mTBI) + substance use (SU) and a TBI -control group; and (2) assess SU-related outcomes at the end of IOP treatment and durability of SU outcomes at 6-months follow-up among SM/Vs with co-occurring SU. Analyses of these key treatment outcomes along with input from lived experience consultants and other key stakeholders, will be used to refine and disseminate a scalable approach to treating individuals with mTBI and co-occurring SU.

Registry
clinicaltrials.gov
Start Date
February 2025
End Date
August 2028
Last Updated
last year
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Sponsor
Shepherd Center, Atlanta GA
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • At least 18 years of age
  • US military service member or veteran
  • Diagnosis of mild traumatic brain injury (mTBI) and/or repetitive head impact/blast exposures
  • Participating in the SHARE Military Initiative intensive outpatient program

Exclusion Criteria

  • History of brain injury other than mTBI or progressive neurological disorder
  • Active psychosis
  • Not able to provide consent

Outcomes

Primary Outcomes

Neurobehavioral Symptom Inventory (NSI)

Time Frame: Study enrollment, immediately after the intervention, and at 6 months follow-up

a 22-item, self-report questionnaire used to measure change in symptoms commonly associated with mild traumatic brain injury over time

Short Inventory of Problems- Revised (SIP-R)

Time Frame: Study enrollment, immediately after the intervention, and at 6 months follow-up

a 17-item self-report inventory used to assess adverse consequences of substance use

Secondary Outcomes

  • Life-Satisfaction Questionnaire -11 (LISAT-11)(Study enrollment, immediately after the intervention, and at 6 months follow-up)
  • Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5)(Study enrollment, immediately after the intervention, and at 6 months follow-up)
  • Patient Health Questionnaire (PHQ-8)(Study enrollment, immediately after the intervention, and at 6 months follow-up)
  • Generalized Anxiety Disorder Scale (GAD-7)(Study enrollment, immediately after the intervention, and at 6 months follow-up)
  • Repeatable Battery for the Assessment of Neuropsychological Status Update (RBANS Update)(Study enrollment and immediately after the intervention)
  • Sensory Organization Test (SOT)(Study enrollment and immediately after the intervention)
  • Behavior Rating Inventory of Executive Functioning - Adult Version (BRIEF-A)(Study enrollment and immediately after the intervention)
  • Alcohol Use Disorders Identification Test- Concise (AUDIT-C)(Study enrollment and at 6 months follow-up)
  • Drug Abuse Screening Test (DAST-10)(Study enrollment and at 6 months follow-up)
  • Cannabis Use Disorder Identification Test (CUDIT-R)(Study enrollment and at 6 months follow-up)
  • National Survey on Drug Use and Health (NSDUH)- 30-day use: Alcohol and Substances(Study enrollment, immediately after the intervention, and at 6 months follow-up)

Study Sites (1)

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