Effect of thoracic epidural anesthesia (TEA) on right ventricular function and ventricular-pulmonary coupling.
Completed
- Conditions
- TEA-RV function- ventricular pulmonary coupling
- Registration Number
- NL-OMON21044
- Lead Sponsor
- eiden University Medical Center (LUMC)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Patients undergoing lungresection.
Exclusion Criteria
Contra indication epidural anesthesia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pressure–volume signals acquired during steady state yield end-diastolic and end-systolic volume (EDV, ESV), ejection fraction (EF), end-diastolic and end-systolic pressure (EDP, ESP), stroke work (SW), dP/dtMAX and dP/dtMIN, and isovolumic relaxation time constant Tau. The end-systolic pressure–volume relation (ESPVR: ESP vs. ESV) and the preload recruitable stroke work relation (PRSWR: SW vs. EDV) quantify systolic ventricular function. The slope of the ESPVR determines end-systolic elastance Ees. The end-diastolic pressure-volume relation (EDPVR: EDP vs. EDV) is used to determine diastolic function, quantified by diastolic chamber stiffness and the stiffness constant.<br>Right ventricular afterload is determined by effective arterial elastance Ea, calculated as ESP/SV. Ventricular-arterial coupling is quantified as Ees/Ea.
- Secondary Outcome Measures
Name Time Method ECG, Heart rate (beats/min), NIBP (mmHg), SpO2 (%), Systolic Blood Pressure (mmHg), Diastolic Blood Pressure (mmHg), Mean Arterial Pressure (mmHg), Cardiac Output (l/min).