Influence of Square-stepping Exercise on Brain Activation, Cognitive Function and Physical Performance in Frail Elders With MCI

Recruiting

• Conditions: Frailty; Mild Cognitive Impairment

• Registration Number: NCT05173363
• Lead Sponsor: National Yang Ming Chiao Tung University

Brief Summary

This study is to elucidate the possible mechanisms of SSE by examining brain activation differences between SSE patterns and usual walking, as well as the relationship between brain activity and SSE performance, between cognitive function and SSE performance, and between physical performance and SSE performance in frail elders with MCI.

Detailed Description

Background:

Both frailty and MCI exert negative impact on motor and cognitive function, which increase the risks of fall and adverse health condition. SSE has been proved to be an effective intervention for motor and cognitive function in older adults. However, the underlying mechanisms of SSE still remain undetermined for its possible effects. This study aims to elucidate the possible mechanisms of SSE in frail elders with MCI.

Methods:

This is a cross-sectional study. The inclusion criteria are: (1) age between 65 and 90 years old, (2) the presence of at least 1 characteristic of the Fried frailty criteria, (3) with mini-mental state examination (MMSE) score≧24 and Montreal Cognitive Assessment (MoCA) score \<26 (MCI criteria), and (4) ability to walk independently for 1 min without assistive devices. The exclusion criteria are: (1) central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury), and (2) any unstable physical condition, psychiatric disorder, and other neurological disorder or diagnosed with learning disability which may affect participating this study. Brain activity during SSE and usual walking, SSE performance, physical performance, and cognitive function are measured. The purpose of this study is to elucidate the possible mechanisms of SSE by examining brain activation differences between SSE patterns and usual walking, as well as the relationship between brain activity and SSE performance, between cognitive function and SSE performance, and between physical performance and SSE performance in frail elders with MCI.

Study Timeline

• Study First Submitted: 2021-12-05
• Study First Submitted QC: 2021-12-20
• Study First Posted: 2021-12-29
• Study Start: 2022-02-09
• Status Verified: 2022-09
• Last Update Submitted: 2022-10-12
• Last Update Posted: 2022-10-14
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age between 65 and 90 years old
• Presence of at least 1 characteristic of the Fried frailty criteria
• Mini-mental state examination score equal to or more than 24
• Montreal Cognitive Assessment score less than 26
• Ability to walk independently for 1 min without assistive devices

Exclusion Criteria

• Central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury)
• Any unstable physical condition, psychiatric disorder, and other neurological disorder or diagnosed with learning disability which may affect participating this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Trail making test	5 minutes	Executive function
SSE performance	15 minutes	The number of the correct steps that participants complete in 1 min during SSEs will be recorded
Digit span test	8 minutes	Executive function
Berg balance scale	15 minutes	Balance and fall risk
Five times sit to stand test	3 minutes	Lower extremity strength
Brain activity	20 minutes	The brain activity will be measured under 3 tasks: usual walking, SSE-pattern1 (SSE1), and SSE-pattern 2 (SSE2)
Montreal Cognitive Assessment	15 minutes	Global cognitive function
Stroop color and word test	5 minutes	Executive function
Timed up and go test	5 minutes	Dynamic balance and functional mobility

Trial Locations

Locations (1)

National Yang Ming Chiao Tung University; 🇨🇳 Taipei, Taiwan