The Effect of Surgical Humidification in Colorectal Cancer Surgery: a Randomised Controlled Trial
Not Applicable
- Conditions
- colorectal cancerCancer - Bowel - Back passage (rectum) or large bowel (colon)Surgery - Surgical techniques
- Registration Number
- ACTRN12622000007730
- Lead Sponsor
- Epworth Hospital
- Brief Summary
This prospective RCT is in accord with previous animal studies showing insufflation using dry-cold carbon dioxide (DC-CO2) leads to peritoneal cellular damage, inflammation and hypothermia compared humidified warm-CO2 (HW-CO2). while importantly highlighting pre-existing peritoneal damage in some patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Stopped early
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
All patients undergoing elective colorectal cancer surgery for any indication
Exclusion Criteria
•Patients under age 18
•Patients with known intra-abdominal sepsis
Pre-operative steroid dependence
Patients who are pregnant
Prior diagnosis of Crohns or ulcerative colitis
Inability to consent due to cognitive or language barrier
Preoperative blood transfusion
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment of peritoneal tissue damage, as measured by peritoneal morphological changes.<br><br>[Peritoneal fluid and peritoneal biopsies will be taken at the start of the operation, then 2-hourly intra-operatively. ]
- Secondary Outcome Measures
Name Time Method