Skip to main content
MedPathMedPath Home
Clinical Trials/CTRI/2018/05/013773
CTRI/2018/05/013773
Completed
Phase 3

A Comparative Study Of Induction Chemotherapy Followed By Radiotherapy Versus Concurrent Chemo Radiotherapy In Locally Advanced Squamous Cell Carcinoma Of Oesophagus : A Randomized Controlled Trial.

IPGMER Fluid Research Fund0 sites40 target enrollmentTBD
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsHealth Condition 1: null- Locally Advanced Squamous Cell Carcinoma Of Oesophagus.

Overview

Phase
Phase 3
Intervention
Not specified
Conditions
Health Condition 1: null- Locally Advanced Squamous Cell Carcinoma Of Oesophagus.
Sponsor
IPGMER Fluid Research Fund
Enrollment
40
Status
Completed
Last Updated
4 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
4 years ago
Study Type
Interventional

Investigators

Sponsor
IPGMER Fluid Research Fund

Eligibility Criteria

Inclusion Criteria

  • •1\. Histological proven squamous cell carcinoma of oesophagus.
  • •2\. Locally advanced stage, clinically defined as a T3N0 or T3N1 tumour according to the 1997 UICC classification, or stage T2N0 or T2N1,.
  • •3\. ECOG performance status 2 or less.
  • •4\. Hematologic, hepatic, and renal functions with in normal limit.

Exclusion Criteria

  • •1\. Previous radiotherapy, chemotherapy and surgical oesophageal treatment (Except laser therapy).
  • •2\. Pregnancy and lactating mother.
  • •3\. Known hypersensitivity to the chemotherapy drugs / irradiation under study.
  • •4\. Abnormal initial haematology e.g.
  • •a. Haemoglobin \< 10 gm%.
  • •b. Platelets \< 75000/mm3\.
  • •c. Absolute Neutrophil Count (ANC) \< 1000/mm3\.
  • •d. Serum bilirubin \> 2 .5 times the upper limit of the reference range (ULRR).
  • •e. Alanine amino\-transferase (ALT or SGPT) or Aspartate amino\-transferase(AST or SGOT) \>5 times the ULRR.
  • •f. Creatinine \> 2\.0 times the ULRR,

Outcomes

Primary Outcomes

Not specified

Similar Trials

Completed
Phase 2
The phase II study of induction chemotherapy with cetuximab/S-1/low dose cisplatin for oral squamous cell carcinoma patientsoral squamous cell carcinoma
JPRN-UMIN000014632The workshop of chemotherapy for oral cancer55
Completed
Phase 2
Evaluation of treatment outcome of induction chemotherapy and then Neoadjuvant chemoradiotherapy and surgery in locally advanced rectal cancer
IRCT20200420047139N1Shahid Beheshti University of Medical Sciences30
Not yet recruiting
Phase 2
A Prospective Study Comparing Induction Chemotherapy Followed By Chemoradiation Versus Chemoradiation Alone In Stage III Non Small Cell Lung Cancer
CTRI/2019/09/021436sskm radiotherapy department
Active, not recruiting
Phase 1
Phase I/II study of Induction Chemotherapy with weekly RAD001, Carboplatine and Paclitaxel in Unresectable or Inoperable Locally Advanced Head and NeckSquamous Cell Carcinoma (HNSCC) - CAPRAnresectable or Inoperable locally advanced head and neck squamous cellcarcinoma without any prior chemotherapy or radiotherapyMedDRA version: 9.1Level: PTClassification code 10041823Term: Squamous cell carcinoma
EUCTR2008-005702-39-FRGERCOR50
Completed
Phase 1
Phase I/II study of induction chemotherapy with docetaxel,cisplatin and fluorouracil (DCF) followed by chemoradiotherapy in patients with unresectable locally advanced esophageal carcinoma.esophageal neoplasm
JPRN-UMIN000003370ational Cancer Center Hospital East30