Comparing the effects of two different anesthetic agents (Propofol and Sevoflurane) on the blood flow and oxygen concentration in the brain with patients lying face dow
Not Applicable
- Conditions
- Health Condition 1: O- Medical and SurgicalHealth Condition 2: G952- Other and unspecified cord compression
- Registration Number
- CTRI/2022/09/045560
- Lead Sponsor
- DR GEETHA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients aged 18 ââ?¬â?? 65 years
2.ASA 1 and 2
3.Elective thoracolumbar spinal surgeries
Exclusion Criteria
1.Unable to insonate the MCA
2.Re exploration procedures
3.Carotid artery disease
4.Presence of intracranial pathology (intracranial space occupying lesions, meningitis, stroke, traumatic brain injury)
5.Intraoperative dye utilization or blood transfusion
6.Intraoperative SSEP and MEP recording
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To compare the cerebral blood flow (MCA velocity and PI using TCD) between Propofol and Sevoflurane based anaesthesia in prone position <br/ ><br>2.To compare the cerebral oxygenation (rSO2 using NIRS) between Propofol and Sevoflurane based anaesthesia in prone position <br/ ><br>Timepoint: The baseline Cerebral Hemodynamics and Oxygenation parameters will be recorded prior to Surgery, Using Transcranial doppler ultrasound (TCD) and Near infra red spectroscopy.After proning post induction of anesthesia recordings shall be taken every 15 minutes for the first 1 hour, then every 30 minutes for next 2 hours and hourly there after. final recordings shall be taken in the recovery room
- Secondary Outcome Measures
Name Time Method To assess the outcome in terms of MMSE (Mini Mental State Examination)Timepoint: A baseline in the pre operative area and in the recovery room after extubation