A randomized phase 2 study comparing different dose-approaches of induction treatment (first cycle) of regorafenib in metastatic colorectal cancer (mCRC) patients.

Phase 1

• Conditions: Metastatic colorectal cancer.; MedDRA version: 19.1Level: LLTClassification code 10052362Term: Metastatic colorectal cancerSystem Organ Class: 100000004864; Therapeutic area: Diseases [C] - Cancer [C04]

• Registration Number: EUCTR2016-000640-34-FR
• Lead Sponsor: Grupo de Tratamiento de los Tumores Digestivos (TTD)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-03-21
• Last Update Posted: 7 January 2019

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 295

Inclusion Criteria

1. Signed informed consent (IC) obtained before any study specific procedures. Subjects must be able to understand and willing to sign a written informed consent.
2. Male or female subjects 18 years of age.
3. Life expectancy of at least 3 months.
4. Histological or cytological documentation of adenocarcinoma of the colon or rectum. All other histological types are excluded.
5. Measurable metastatic stage IV disease with at least 1 measurable metastatic lesion following RECIST criteria v 1.1 and be documented by radiological evaluation.
6. Subjects with metastatic colorectal cancer (Stage IV).
7. Progression during or within 3 months following the last administration of approved standard therapies which must include fluoropyrimidine, oxaliplatin, irinotecan, an anti-VEGF and an anti-EGFR (if RAS WT).
8. Subjects treated with oxaliplatin in an adjuvant setting should have progressed during or within 6 months of completion of adjuvant therapy.
9. Subjects who progress more than 6 months after completion of oxaliplatin containing adjuvant treatment must be retreated with oxaliplatin-based therapy to be eligible. Subjects who have withdrawn from standard treatment due to unacceptable toxicity warranting discontinuation of treatment and precluding retreatment with the same agent prior to progression of disease will also be allowed into the study.
10. ECOG Performance Status of 0 or 1(within 14 days prior to the initiation of study treatment).
11. Adequate bone marrow, liver and renal function as assessed by the following laboratory requirements:
a. Total bilirubin = 1.5 x the upper limit of normal (ULN).
b. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) = 2.5 x ULN (5 x ULN for subjects with liver involvement of their cancer).
c. Alkaline phosphatase limit = 2.5 x ULN (5 x ULN for subjects with liver and/or bone involvement of their cancer).
d. Lipase = 1.5 x the ULN.
e. Serum creatinine 1.5 x the ULN or = 30 mL/min as calculated using the Cockcroft-Gault equation.
f. Platelet count >100000/mm3, hemoglobin >9 g/dL, absolute neutrophil count (ANC) >1500/mm3.
g. International normalized ratio (INR)/ Partial thromboplastin time (PTT) 1.5 x ULN. (Subjects who are therapeutically treated with an agent such as
warfarin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in coagulation parameters exists. Close
monitoring of at least weekly evaluations will be performed until INR/PTT is stable based on a measurement that is pre-dose as defined by the local
standard.
h. Blood transfusion to meet the inclusion criteria will not be allowed.
12. Women of childbearing potential and men must agree to use adequate contraception before entering the program until at least 8 weeks after the last study drug administration. The investigator or a designated associate is requested to advise the subject on how to achieve an adequate birth control. Adequate contraception is defined in the study as any medically recommended method (or combination of methods) as per standard of care.
Women of childbearing potential must have a blood or urine pregnancy test performed a maximum of 7 days before start of study treatment, and a negative result must be documented before start of study treatment.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 95
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subje

Exclusion Criteria

1. Prior treatment with regorafenib.
2. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days before start of study drug.
3. Pregnant or breast-feeding subjects.
4. Congestive heart failure = New York Heart Association (NYHA) class 2.
5. Unstable angina (angina symptoms at rest), new-onset angina (begun within the last 3 months).
6. Myocardial infarction less than 6 months before start of study drug.
7. Cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted).
8. Uncontrolled hypertension. (Systolic blood pressure > 140 mmHg or diastolic pressure > 90 mmHg despite optimal medical management).
9. Arterial or venous thromboembolism within 6 months prior to randomization.
10. Pleural effusion or ascites that causes respiratory compromise (CTCAE Grade 2 dyspnea).
11. Ongoing infection > Grade 2 CTCAE v. 4.0.
12. Known history of human immunodeficiency virus (HIV) infection.
13. Known history of active hepatitis B or C, or chronic hepatitis B or C requiring treatment with antiviral therapy.
14. Subjects with seizure disorder requiring medication.
15. History of organ allograft.
16. Subjects with evidence or history of any bleeding diathesis, irrespective of severity.
17. Any hemorrhage or bleeding event = CTCAE Grade 3 within 4 weeks prior to the start of study medication.
18. Non-healing wound, ulcer, or bone fracture.
19. Renal failure requiring hemo-or peritoneal dialysis.
20. Dehydration CTCAE v. 4.0 Grade = 1.
21. Substance abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or evaluation of the study results.
22. Known hypersensitivity to any of the study drugs, study drug classes, or excipients in the formulation.
23. Any illness or medical conditions that are unstable or could jeopardize the safety of the subject and his/her compliance in the study.
24. Interstitial lung disease with ongoing signs and symptoms.
25. Persistent proteinuria of CTCAE Grade 3 (>3.5g/24 hours).
26. Subjects unable to swallow oral medications.
27. Any malabsorption condition.
28. Unresolved toxicity higher than CTCAE (v. 4.0) > Grade 1 attributed to any prior therapy/procedure excluding alopecia, hypothyroidism and oxaliplatin induced neurotoxicity > Grade 2.
29. Subjects treated with strong CYP3A4 inhibitors or inducers (refer to appendix 8 and to section 6.3.8. Prohibited concomitant medication).
30. Subjects receiving G-CSF within 3 weeks prior to signing the ICF.
31. Concomitant participation or participation within the last 30 days in another clinical trial.
32. Systemic anticancer therapy including cytotoxic therapy, signal transduction inhibitors, immunotherapy, and hormonal therapy during this trial or within 4 weeks (or within 6 weeks for mitomycin C) before starting to receive study medication.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: To evaluate the safety and tolerability of different dose-escalation approaches of regorafenib in mCRC patients.;Secondary Objective: Percentage of total administrated dose over the planned dose accomplished in each arm.<br>Dose intensity during the whole treatment.<br>Dose intensity during first two cycles.<br>Disease control rate (DCR).<br>Progression-free survival (PFS).<br>Time to treatment failure (TTF).<br>Overall survival (OS).;Primary end point(s): Percentage of patients with G3/G4 treatment-related AEs in each arm according to CTCAE v4.03 criteria.;Timepoint(s) of evaluation of this end point: During treatment and follow-up period.