nderstanding the barriers to successful treatment of newly diagnosed severe hypertension: an interventional study

Royal Devon & Exeter Hospital0 个研究点目标入组 100 人开始时间: 2015年6月25日最近更新: 2022年3月21日

适应症

试验速览

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34689818/ (added 26/10/2021) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/35246164/ (added 07/03/2022)

•1. New diagnosis of severe hypertension with systolic blood pressure greater than or equal to 170mmHg on screening and when repeated by the study team using the standard operating procedure for blood pressure measurement
•2. No present or historical anti-hypertensive agent prescription
•3. Aged 18-79 years inclusive

•1. Inability to give informed consent
•2. Significant renal dysfunction as defined by eGFR <60 ml/min/1.73m2 by Modification of Diet in Renal Disease Study (MDRD) formula
•3. Previous or current prescription of any medication used in the study protocol
•4. Previous renal artery intervention
•5. Bleeding diathesis
•6. Haemoglobin <10 g/dl
•7. Platelet count <100 x109/l
•8. Inability to provide informed consent
•9. Pregnancy
•10. Hypertension related event (including stroke or acute kidney injury) within the preceding 3 months.
•11. Any condition, including hypertensive urgency, which requires more immediate BP lowering or tailored anti-hypertensive strategy at enrolment

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