NCT01943968UnknownNot Applicable
Lysyl Oxidase, Semaphorin 7a and Semaphorin 3a in Patients With Systemic Sclerosis
Hillel Yaffe Medical Center1 site in 1 country30 target enrollmentStarted: December 2013Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Hillel Yaffe Medical Center
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Fibrin Enzyme Levels in Blood
Study Overview
Brief Summary
The aim of our study is to find a biomarker for fibrosis or vasculopathy in systemic sclerosis. We will evaluate a possible correlation between semaphorin 7a, semaphorin 3a and lysyl oxidase and fibrosis (lung and skin) or vasculopathy in patients with systemic sclerosis. The results obtained may help us diagnose these complications of systemic sclerosis and hopefully even monitor patient treatment.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Systemic Sclerosis Patients
- •Written consent to participation in study
Exclusion Criteria
- •Serious active medical condition
- •Other autoimmune rheumatic disease
- •Current or past allergic/inflammatory reaction
- •Liver disease
- •Pregnant or breastfeeding
- •Illegal drug or alcohol abuse
Outcomes
Primary Outcomes
Fibrin Enzyme Levels in Blood
Time Frame: Six months
Patients will undergo blood tests before study and after six months to determine levels of lysyl oxidase, semaphorin 7a and 3a and thus determine severity of the disease (systemic sclerosis).
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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