Hokkaido-Losartan/hydrochlorothiazide Investigation For End Point (H-LIFE study): Multi-center observational study on blood pressure control and cardio- and renoprotective effects of an ARB / diuretic combination in hypertensive patients in Hokkaido, Japa
Not Applicable
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000001257
- Lead Sponsor
- Hokkaido Clinical Hypertension Research Group
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 1000
Inclusion Criteria
Not provided
Exclusion Criteria
1)Patients with a history of hypersensitivity to ingredients of losartan/HCTZ 2)Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 3)Pregnant (positive on a urine pregnancy test prior to the study) or breast feeding female patients, including one trying to conceive pregnancy during the planned study period 4)Patients with sever liver dysfunction 5)Patients with anuria or on dialysis 6)Patients with acute renal failure 7)Patients whose sodium and potassium levels in body fluids are clearly decreased
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Change in office blood-pressure 2.Change in BNP and NT-proBNP levels 3.Change in microalbuminuria, proteinuria and renal function
- Secondary Outcome Measures
Name Time Method 1.Frequency of cardiovascular events (fatal and non-fatal myocardial infarction, unstable angina, angina that required hospitalization, coronary revascularization, stroke etc) 2.Frequency of renal events (end-stage renal disease [ESRD], deterioration in renal function, etc) 3.Mortality 4.Rates of adverse events 5.Exploratory subgroup analysis