Retinal Pigment Epithelial Characteristics in Eyes With Neovascular Age-related Macular Degeneration Following Long-term Treatment With Anti Neovascular Endothelial Growth Factor
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 18
- 主要终点
- visual acuity
研究概览
简要总结
Purpose:
To assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) during long-term follow-up and to evaluate morphological markers potentially influencing prognosis.
Methods:
18 patients (18 eyes) with neovascular AMD were recruited subsequent to completion the Avastin Versus Lucentis in Age Related Macular Degeneration (MANTA) study following a mean period of 84 months (range: 69-93 months). After receiving a loading dose of 3 intravitreal anti-VEGF injections subsequent to baseline of the MANTA study, patients were treated as-needed [pro re nata (PRN)]. Functional and morphological changes were assessed using spectral domain optical coherence tomography (SD-OCT).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 66 Years 至 98 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inclusion and exclusion criteria corresponded to the criteria of the MANTA study
排除标准
- •Inclusion and exclusion criteria corresponded to the criteria of the MANTA study
结局指标
主要结局
visual acuity
时间窗: 93 months
visual acuity testing was performed
次要结局
未报告次要终点
研究者
Dr. Clara Wernigg
Dr.
Hospital Hietzing