Specular Endothelial Changes in Diabetic and Non-diabetic Patients Undergoing Phacoemulsification
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Al-Azhar University
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Cell density
Study Overview
Brief Summary
The aim of this study is to evaluate and compare specular endothelial changes in diabetic and non-diabetic patients undergoing phacoemulsification by assessing endothelial cell density, coefficient of variation, and percentage of hexagonal cells preoperatively and postoperatively. This study also seeks to provide updated evidence on the influence of diabetes on corneal endothelial response to cataract surgery and to support evidence-based strategies for optimizing surgical outcomes
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 40 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age ≥ 40 years
- •Presence of senile cataract suitable for phacoemulsification
- •Clear cornea with no clinical signs of endothelial decompensation
- •Ability to undergo specular microscopy examination
- •For the diabetic group: confirmed diagnosis of type 2 diabetes mellitus
Exclusion Criteria
- •History of previous ocular surgery or trauma
- •Corneal pathology affecting the endothelium
- •Glaucoma or history of raised intraocular pressure
- •Pseudoexfoliation syndrome
- •Intraoperative complications
Arms & Interventions
Diabetic group
Intervention: Phacoemulsification (Procedure)
Non-Diabetic group
Intervention: Phacoemulsification (Procedure)
Outcomes
Primary Outcomes
Cell density
Time Frame: 1 week
Cell density
Time Frame: 1 month
Cell density
Time Frame: 3 months
Secondary Outcomes
No secondary outcomes reported
Investigators
Ehab Tharwat
Principal Invistigator
Al-Azhar University