A clinical trial to study the effect of early body and respiratory muscle exercises on withdrawing breathing machine support in patients with long-lasting lung disease.
Not Applicable
- Conditions
- Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecified
- Registration Number
- CTRI/2022/10/046512
- Lead Sponsor
- Pentamed Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Age > 18 years.
Intubated.
Receiving Mechanical Ventilation in ICU > 48 hours.
COPD Patients of type 2 respiratory failure.
Patients with Maximum inspiratory pressure (PIMAX): 15 to 30 cm H2O.
Rapid shallow breathing index (RSBI): 60â??105
Exclusion Criteria
Unable to perform test manoeuvre.
Any pre-existing neuromuscular disease.
Any Associated Pulmonary Disease.
Acute coronary syndrome (ACS).
Haemoptysis.
Spinal cord injury above T8.
Any skeletal pathology that impairs chest wall movements such as severe kyphoscoliosis congenital deformities or contractures.
Poor general prognosis or anticipated fatal outcome.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method weaning success. <br/ ><br>Duration of mechanical ventilation (days). <br/ ><br>Reintubation. <br/ ><br>Tracheostomy. <br/ ><br>Length of ICU stay and hospital stay (days). <br/ ><br>Mortality. <br/ ><br>Adverse events in patients. <br/ ><br>Timepoint: Till hospital discharge/death of the patient, whatever comes first <br/ ><br>
- Secondary Outcome Measures
Name Time Method Arterial blood gas (ABG). <br/ ><br>Inspiratory muscle strength (Plmax). <br/ ><br>Rapid shallow breathing index (RSBI) i.e Lung compliance associated with adequate gas exchange and lower respiratory rate. <br/ ><br>Measurement of diaphragm thickness and function by ultrasound. <br/ ><br>Timepoint: Till hospital discharge/death of the patient, whatever comes first <br/ ><br>