Intranasal ketamine for moderate to severe pain in children- a dose finding study.
- Conditions
- acute painmusculoskeletal injuryAnaesthesiology - Pain managementInjuries and Accidents - Other injuries and accidents
- Registration Number
- ACTRN12612000012875
- Lead Sponsor
- Southern Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Children aged three to 13 years and under 50kg body weight
Musculoskeletal injury to upper and/or lower limbs
Visual analog pain score greater than or equal to 6/10 on the standard 11-point verbal rating scale (0 = none, 10 = worst pain imaginable) and patient would normally be considered for intranasal fentanyl administration.
Use of simple analgesia such as paracetamol or ibuprofen or inhalational methoxyflurane during ambulance transport are not exclusion criteria
Inability to gain informed consent from parent or guardian
Prior administration of parenteral or intranasal analgesics (morphine, fentanyl)
Prior administration of oral opioid analgesia (oxycodone, codeine)
Allergy to ketamine
Aberrant nasal anatomy
Acute or chronic nasal problems or nasal trauma that may preclude adequate administration or absorption of intranasal medication.
Presence of multiple trauma or injuries.
Sustained a head injury with loss of consciousness.
Presence of cognitive impairment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean change in Visual Analog Scale pain score from pre-administration (T0) to 30 minutes post-administration (T30)[30 minutes post-administration of ketamine]
- Secondary Outcome Measures
Name Time Method