Assessment of the Effect of Atorvastatin on Prevention of CIN in Patients Undergoing Coronary Angiography
- Registration Number
- NCT02113540
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
As the effect of statin use before the angiography to prevent contrast induced nephropathy (CIN) is not well-known, the aim of the current study is to assess the effect of atorvastatin on prevention of CIN in patients undergoing coronary angiography.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- having chronic stable angina who were referred for coronary angiography
- non-pregnant female subjects
- no history of diabetes mellitus
- no history of renal failure
- no history of single kidney
- no history of cardiogenic shock
- no history of unstable angina
- no history of myocardial infarction
- no history of hypersensitivity to statins
- no history of previous intravascular contrast injection during one month before admission
Exclusion Criteria
- glomerular filtration rate (GFR) <60
- cardiogenic shock
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description preoperation statin group Atorvastatin taking atorvastatin 12 hours before the procedure
- Primary Outcome Measures
Name Time Method Contrast induced nephropathy (CIN) incidence 48 hours after the procedure CIN is determined as an increase in post-procedural serum creatinine of \> 0.5 mg/dl or \> 25% from baseline in the absence of any other causes
- Secondary Outcome Measures
Name Time Method serum creatinine (Cr) level 48 hours after the procedure