临床试验/NCT02113540

NCT02113540Unknown3 期

Atorvastatin and Prevention of Contrast Induced Nephropathy Following Coronary Angiography

Isfahan University of Medical Sciences0 个研究点开始时间: 2012年1月最近更新: 2014年4月14日

适应症

干预措施

试验速览

阶段: 3 期
发起方: Isfahan University of Medical Sciences
主要终点: Contrast induced nephropathy (CIN) incidence

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者记录与标识符相似试验

研究概览

简要总结

As the effect of statin use before the angiography to prevent contrast induced nephropathy (CIN) is not well-known, the aim of the current study is to assess the effect of atorvastatin on prevention of CIN in patients undergoing coronary angiography.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Prevention
盲法: Triple (Participant, Care Provider, Investigator)

入排标准

性别: All
接受健康志愿者: 否

入选标准

•having chronic stable angina who were referred for coronary angiography
•non-pregnant female subjects
•no history of diabetes mellitus
•no history of renal failure
•no history of single kidney
•no history of cardiogenic shock
•no history of unstable angina
•no history of myocardial infarction
•no history of hypersensitivity to statins
•no history of previous intravascular contrast injection during one month before admission

排除标准

•glomerular filtration rate (GFR) <60
•cardiogenic shock

研究组 & 干预措施

preoperation statin group

Experimental

taking atorvastatin 12 hours before the procedure

干预措施: Atorvastatin (Drug)

结局指标

主要结局

Contrast induced nephropathy (CIN) incidence

时间窗: 48 hours after the procedure

CIN is determined as an increase in post-procedural serum creatinine of \> 0.5 mg/dl or \> 25% from baseline in the absence of any other causes

次要结局

serum creatinine (Cr) level(48 hours after the procedure)

研究者

发起方

Isfahan University of Medical Sciences

申办方类型

Other

责任方

Principal Investigator

主要研究者

peyman bidram

Dr peyman bidram

Isfahan University of Medical Sciences

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