MedPath

Novel MRI Sequence- MR Fingerprinting

Not Applicable
Completed
Conditions
Disease
Interventions
Device: MR Fingerprinting
Registration Number
NCT03722459
Lead Sponsor
University of North Carolina, Chapel Hill
Brief Summary

Magnetic Resonance Imaging (MRI) has become one of most important medical imaging tools over the past 30 years because it is non-invasive, requires no ionizing radiation, and provides exquisite images of soft tissues and anatomic structures with many tissue/disease specific contrasts. While MRI has served the community well for many years, it is increasingly clear that it also has significant limitations.

One of the principle limitations is the lack of quantitative information for tissue/structure characterization. The current paradigm of MRI is to use a set of scanner settings to generate an image "weighted" by a specific MR contrast mechanism (physical parameter), where it is hoped that variations in the parameter will be accentuated. However, without quantitative knowledge of the parameters, the final image contrast may depend on many factors, which complicates image interpretation and diagnostic performance. Quantitative measurement can provide a great deal of information about tissue properties and pathological conditions, since these parameters ultimately determine the contrast that is observed in conventional images.

Detailed Description

The purpose of this study is to evaluate novel quantitative MRI techniques in clinical studies to determine whether they can provide better, faster and more useful information for clinical diagnosis. In this study, the investigators propose to apply MR Fingerprinting and evaluate its performance for different diseases. These include, but are not limited to, diseases in the liver, kidney, cardiac, pancreas etc. The investigators hypothesize that the quantitative MR Fingerprinting imaging technique will lead to improved tissue characterization and diagnosis.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
22
Inclusion Criteria
  • The study will include English-speaking patients that are already scheduled to undergo a clinical MRI for diagnostic purposes.
Read More
Exclusion Criteria
  • Pregnant women will be excluded.
  • Women will be excluded from the healthy volunteers, due to a lack of funding for pregnancy testing. Funding for this will be considered for the future.
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
All participantsMR FingerprintingAll participants will receive the investigational MR Fingerprinting sequence.
Primary Outcome Measures
NameTimeMethod
Percent of Patients With Visible Region of Interest (Imaging Visibility)Immediately following MRI completion, within approximately 5 minutes

MR fingerprinting sequences will be examined to determine their utility for visualizing pathology.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

University of North Carolina at Chapel Hill

🇺🇸

Chapel Hill, North Carolina, United States

© Copyright 2025. All Rights Reserved by MedPath