Topical Methotrexate in the Treatment of patches of Hair Fall

Phase 3

Not yet recruiting

Brief Summary: This study is an interventional study being done on subjects of Alopecia Areata. The Study involves comparison between effectiveness of Topical application of Methotrexate in combination with Topical Tretinoin versus Topical Betamethasone with Topical Tretinoin. The study duration will be for one year and the estimated sample size will be 80 such that 40 will be in each group. The results will be compared as per the hair regrowth percentage status as compared with the initial affected area.

Recruitment & Eligibility

Inclusion Criteria

Patients of Alopecia Areata of at least 2 months duration Patients having patches in 1-3 numbers over the scalp.
Patients who are willing to take part in the study with signed and written informed consent.
Patients could be of both male and female.
All patients who are 18 years and above of age Patient must be medically stable.
Patient must have active mobile number.

Exclusion Criteria

Patients who are not willing to sign in after informed consent.
Pregnant, breast feeding, child bearing age using contraception.
Patient with Alopecia Totalis and Alopecia Universalis Patient with a K/C/O any Autoimmune conditions like SLE, Thyroid disorder, Vitiligo, etc.
Patient receiving systemic treatment relevant to alopecia areata within 3 months of enrollment.
Patient receiving Topical treatment relevant to Alopecia areata within 2 months Patient with any Fungal infection of scalp Patient with dermatological conditions affecting skin other than Alopecia Areata.
Patient with psychiatric illness or psychological state interfering with compliance.

Primary Outcome Measures

Name	Time	Method
To Observe the Effect of Test Drugs on Hair Regrowth in the patients of Alopecia Areata using Alopecia Grading Scale (AGS) and Alopecia Regrowth Score (RGS).	Baseline on the day of enrollment \| 1st,2nd and 3rd month
To compare the efficacy between both the groups	Baseline on the day of enrollment \| 1st,2nd and 3rd month

Secondary Outcome Measures

Name	Time	Method
To check any adverse effects of the the test drugs	End of 1st, 2nd and 3rd month

Locations (1): J A Group of Hospitals
🇮🇳
Gwalior, MADHYA PRADESH, India
J A Group of Hospitals
🇮🇳Gwalior, MADHYA PRADESH, India
Vaibhav Kalgaonkar
Principal investigator
9999742583
vaibhav.kalgaonkar@gmail.com