Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2

Not Applicable

Completed

• Conditions: Behavior, Addictive; Heroin Dependence; Cocaine Dependence; Cocaine Abuse; Opioid Dependence
• Interventions: Behavioral: Contingency management

• Registration Number: NCT00249457
• Lead Sponsor: Johns Hopkins University

Brief Summary

The purpose of this study is to determine whether long-term exposure to the Therapeutic Workplace intervention could sustain drug abstinence over an extended period of time in heroin- and cocaine-dependent, unemployed, treatment-resistant young mothers.

Detailed Description

The current study is a continuation of the research into the development and evaluation of a novel treatment designed to address the chronic, persistent nature of drug addiction. This treatment, called the Therapeutic Workplace, integrates abstinence reinforcement contingencies of proven efficacy into a model supported work program. Participants were paid to work or to train in the Therapeutic Workplace but had to provide drug-free urine samples to gain daily access. Forty participants were randomly assigned to a Therapeutic Workplace or usual care control group. Therapeutic Workplace participants could work for about 5 years. This study reports the effects of the intervention over a follow-up period of 8 years after treatment initiation.

Study Timeline

• Study Start: 1996-10
• Study First Submitted: 2005-11-03
• Study First Submitted QC: 2005-11-03
• Study First Posted: 2005-11-07
• Primary Completion: 2006-01
• Study Completion: 2006-01
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-26
• Last Update Posted: 2017-10-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

• When originally enrolled in the study, participants were at least 18 years old, unemployed, and methadone maintenance patients of the Center for Addiction and Pregnancy (CAP) who continued to use opiates or cocaine during CAP treatment.

Exclusion Criteria

• Participants were excluded if they were at risk for suicide at the time of intake or if they had serious psychiatric illness (e.g., schizophrenia).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Therapeutic Workplace	Contingency management	Contingency management. Invited to work in the Therapeutic Workplace. Completed monthly assessments.

Primary Outcome Measures

Name	Time	Method
Percentage of urine samples at the assessments that were negative for cocaine	every 30 days throughout fourth year	(total number of monthly urine samples negative for cocaine/total number of possible urine samples) x 100
Percentage of urine samples at the assessments that were negative for opiates	every 30 days throughout fourth year	(total number of monthly urine samples negative for opiates/total number of possible urine samples) x 100
Percentage of urine samples at the assessments that were negative for cocaine and opiates	every 30 days throughout fourth year	(total number of monthly urine samples negative for cocaine and opiates/total number of possible urine samples) x 100

Secondary Outcome Measures

Name	Time	Method
HIV risk behaviors	every 30 days throughout fourth year
Number of days employed each month	every 30 days throughout fourth year
Percentage of participants employed each month	every 30 days throughout fourth year
Percentage of participants to self-report abstinence at all time points	every 30 days throughout fourth year

Trial Locations

Locations (1)

The Center for Learning and Health; 🇺🇸 Baltimore, Maryland, United States