JPRN-jRCT1051210147招募中3 期
A Randomized Controlled Trial of the Preventive Effect of Haptoglobin Administration on Hemolysis-Related Organ Damage in Patients undergoing Cardiovascular Surgery
Hokka Mai0 个研究点目标入组 140 人开始时间: 2022年1月5日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 发起方
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1.Patients who undergo cardiovascular surgery required cardiopulmpnary bypass
- •2.Patients aged 20 years or older
- •3.Patients who have given written consent to participate in this study
- •4.Patients with a free hemoglobin concentration of more than 50 mg/dL within 2 hours of starting cardiopulmonary bypass
排除标准
- •1.Patients who had already had renal replacemt therapy
- •2.Patients with a preoperative serum creatinine level of 2 mg/dl or higher
- •3.Patients scheduled for surgery involving the descending aorta
- •4.Patients who undergoing MICS (Minimum Invasive Cardiac Surgery)
- •5.Patients with haptoglobin deficiency
- •6.Patients with IgA deficiency
- •7.Patients with hepatic impairment(Bil>2.0mg/dL)
- •8.Patients with hemolytic diseases(Autoimmune haemolytic anaemia, paroxysmal nocturnal haemoglobinuria, hereditary spherocytosis, etc.)
- •9.Immunocompromised and immunosuppressed patients(e.g. patients on immunosuppressive drugs or who have used chemotherapeutic drugs for malignancy within the last year)
- •10.Patients who are deemed inappropriate by the study investigators
研究者
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