Assessment of Serum Level of Interleukin-15 and Interferon Gamma in Alopecia Areata Patients Before and After Baricitinib Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Serum level of Interleukin-15.
研究概览
简要总结
The primary objective of this study was to evaluate the change in serum interferon gamma and Interleukin-15 levels before and after use of oral drug baricitinib therapy. Venous blood samples (5 mL) were collected from each participant at baseline and at six months.
详细描述
Changes at baseline and immediately after 6 mmonths will be analyzed, primary outcome is the changes in serum levels over 6 months, while secondary outcome is changes in the Severity of Alopecia Tool (SALT score) over 6 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults diagnosed clinically with Alopecia Areata.
- •Severity of alopecia tool (SALT) score greater than
- •Only patients with disease duration exceeding six months but less than eight years will be included.
排除标准
- •Patients were excluded if they were pregnant or lactating, and had chronic hepatic or renal disease.
- •Cases diagnosed with malignancy, scalp infections, or other types of alopecia will also excluded from the current study.
- •Recent use of systemic treatment within the last 3 months or topical treatment within the last 4 weeks also will be excluded.
研究组 & 干预措施
Alopecia Areata adults with severity of alopecia tool more than 50 percent.
Adults aged between 18 to 50 years and having a severity of alopecia tool (SALT) score more than 50 pecent.
干预措施: Baricitinib 4 MG Oral Tablet (Drug)
结局指标
主要结局
Serum level of Interleukin-15.
时间窗: At baseline and immediately after 6 months of follow up.
Measuring the serum level of Interleukin-15 at baseline and immediately after 6 months of Baricitinab 4mg oral therapy. Measurement is done using Enzyme-Linked Immunosorbent Assay (ELISA) laboratory technique.
Serum level of Interferon Gamma.
时间窗: Baseline and immediately after 6 months of Baricitinab 4mg oral therapy.
Measuring the serum level of Interferon Gamma at baseline and immediately after 6 months of Baricitinab 4mg oral therapy. Measurement is done using Enzyme-Linked Immunosorbent Assay (ELISA) laboratory technique.
次要结局
- Changes in the Severity of Alopecia Tool (SALT) score(At Baseline and immediately after 6 months of oral Baricitinab 4mg oral therapy.)
研究者
Amal Youssif Habashy
Amal Youssif Habashy
Benha University