An exploration of intestinal bacterial biofilms in Lynch syndrome patients as disease markers for colorectal cancer

Recruiting

• Conditions: ynch syndroom; Colorectal cancer in Lynch syndrome patients; 10017934; 10017991

• Registration Number: NL-OMON43143
• Lead Sponsor: Pathologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 140

Inclusion Criteria

Lynch patients who are scheduled for multiple colonoscopies.
Other patients who are scheduled for multiple colonoscopies. (control)

Exclusion Criteria

- antibiotics in the past 3 months.
- a history with inflammatory diseases of the intestine.
- vaccination to prevent colorectal cancer.
- coagulation disorders or patients taking anti-coagulation medicine.
- a (sub)total colectomie

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Revealing an assocation between the presence of biofilms and the development of<br /><br>colorectal cancer in Lynch patients. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Determining the effects of biofilms on the mucosal tissue of the colon<br /><br>- Determining the effects of biofilms on oncogenesis markers in epithelial cells<br /><br>- Studying which bacteria are present in the biofilm and determining which<br /><br>bacteria could be potentially pathogenic</p><br>