Identification of Risk Factors for Cardiovascular Disease and Cancer in Korean Population: A Prospective Cohort Study

Recruiting

• Conditions: Risk Factor; Cardiovascular Diseases; Malignancy

• Registration Number: NCT05389956
• Lead Sponsor: Ulsan University Hospital

Brief Summary

Cancer and cardiovascular disease are the global leading causes of death. These two disease entities are multifactorial disease that are caused by several factors. The aim of this prospective cohort study was to investigate the status of risk factors profiles and health related behavior in Korean population, and to discover novel risk factors associated with the occurrence of endpoint events.

Detailed Description

This is a single center, observational, prospective cohort study. The primary outcomes include the incidence of MACE (major adverse cardiovascular events) and the incidence of any malignancy. We plan to collect the baseline information at enrollment and the occurrence of clinical endpoint events will be followed for at least 10 years. The study will enroll 510,000 subjects aged ≥19 years who underwent a general health screening in Korea.

Study Timeline

• Study First Submitted: 2022-05-21
• Study First Submitted QC: 2022-05-21
• Study First Posted: 2022-05-25
• Study Start: 2023-01-01
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-18
• Last Update Posted: 2024-03-19
• Primary Completion: 2042-08
• Study Completion: 2052-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 510000

Inclusion Criteria

• Men or women aged 19 years and older who underwent a general health screening at the health promotion center of Ulsan University Hospital (Ulsan, Korea)
• Subjects have to agree to participate by signing a consent

Exclusion Criteria

• Subjects who cannot or reject to sign the consent form.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Major adverse cardiovascular event (MACE)	10 year	A major adverse cardiovascular event (MACE) of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke
Incidence of malignancy	10 year	The occurrence of any malignancy of interest

Secondary Outcome Measures

Name	Time	Method
All-cause death	10 year
Cancer related mortality	10 year
Cardiovascular death	10 year
Myocardial infarction	10 year
Stroke	10 year

Trial Locations

Locations (1)

Ulsan University Hospital; 🇰🇷 Ulsan, Korea, Republic of