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Computed Tomography Perfusion Colorectal Cancer With Tumor Grade

Conditions
Colo-rectal Cancer
Interventions
Radiation: Computed tomography perfusion
Registration Number
NCT03448302
Lead Sponsor
Assiut University
Brief Summary

Colorectal cancer is the third most commonly diagnosed cancer in the world. The 5-years survival rate depends on the tumor stage and grade at patient presentation. Individual treatment strategy based on the tumor stage and grade should be applied to improve the prognosis, So the pre-operative diagnostic evaluation and grading of colorectal cancer are important.

Detailed Description

Diagnosis of cancer colon is usually based on colonoscopy which provides direct visualization of the lesions and allows for biopsies. However the pre-operative specimens from endoscopic biopsies sometimes fail to grade tumor because of the lack of sufficient tissue. Recent improvements in computed tomography have allowed for minimally invasive evaluation of cancer colon. Quantitative iodine density measurement can be used to differentiate low and high grade colorectal cancer. However, debate continues regarding the correlation between tumor grade and computed tomography perfusion parameters of colorectal cancer demonstrating the need for further investigation in this area of research.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
50
Inclusion Criteria
  • Any patient with primary colorectal mass
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Exclusion Criteria
  • Colorectal mass pathologically proved to be benign Female patient at child bearing period with suspected pregnancy Raised renal chemistry Hypersensitivity to contrast.
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Patients with colorectal adenocarcinomaComputed tomography perfusionThe patients will undergo computed tomography perfusion
Primary Outcome Measures
NameTimeMethod
Blood flow of tumorOne month

Accuracy of blood flow of the tumor in prediction of tumor grade in correlation with histopathological results

Secondary Outcome Measures
NameTimeMethod
Mean transient time of the tumorOne month

transient time of the tumor in prediction of tumor grade in correlation with histopathological results

Blood volume of the tumorOne month

Accuracy of blood volume of the tumor in prediction of tumor grade in correlation with histopathological results

Permeability surface of the tumorOne month

Accuracy of permeability surface of the tumor in prediction of tumor grade in correlation with histopathological results

Trial Locations

Locations (1)

Faculty of Medicine

🇪🇬

Assiut, Egypt

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