Computed Tomography Perfusion Colorectal Cancer With Tumor Grade
- Conditions
- Colo-rectal Cancer
- Interventions
- Radiation: Computed tomography perfusion
- Registration Number
- NCT03448302
- Lead Sponsor
- Assiut University
- Brief Summary
Colorectal cancer is the third most commonly diagnosed cancer in the world. The 5-years survival rate depends on the tumor stage and grade at patient presentation. Individual treatment strategy based on the tumor stage and grade should be applied to improve the prognosis, So the pre-operative diagnostic evaluation and grading of colorectal cancer are important.
- Detailed Description
Diagnosis of cancer colon is usually based on colonoscopy which provides direct visualization of the lesions and allows for biopsies. However the pre-operative specimens from endoscopic biopsies sometimes fail to grade tumor because of the lack of sufficient tissue. Recent improvements in computed tomography have allowed for minimally invasive evaluation of cancer colon. Quantitative iodine density measurement can be used to differentiate low and high grade colorectal cancer. However, debate continues regarding the correlation between tumor grade and computed tomography perfusion parameters of colorectal cancer demonstrating the need for further investigation in this area of research.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- Any patient with primary colorectal mass
- Colorectal mass pathologically proved to be benign Female patient at child bearing period with suspected pregnancy Raised renal chemistry Hypersensitivity to contrast.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with colorectal adenocarcinoma Computed tomography perfusion The patients will undergo computed tomography perfusion
- Primary Outcome Measures
Name Time Method Blood flow of tumor One month Accuracy of blood flow of the tumor in prediction of tumor grade in correlation with histopathological results
- Secondary Outcome Measures
Name Time Method Mean transient time of the tumor One month transient time of the tumor in prediction of tumor grade in correlation with histopathological results
Blood volume of the tumor One month Accuracy of blood volume of the tumor in prediction of tumor grade in correlation with histopathological results
Permeability surface of the tumor One month Accuracy of permeability surface of the tumor in prediction of tumor grade in correlation with histopathological results
Trial Locations
- Locations (1)
Faculty of Medicine
🇪🇬Assiut, Egypt