Evaluation of Demographic Variables, Clinical Parameters, Inflammatory Markers and Viruses in Periodontitis Patients With Coronary Artery Diseases
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Periodontal Virus and Inflammatory Markers expression in periodontitis patients with coronary artery disease
研究概览
简要总结
To assess and compare the demographic variables, periodontal parameters, cardiac parameters and the expression of periodontal viruses (CMV, HSV and EBV) and inflammatory biomarkers(PTX-3, TLR-2 & TLR-4) in periodontally healthy and generalized periodontitis patients with and without coronary artery disease(CAD).
详细描述
A total of 240 subjects will be recruited based on the power of the study. The selected subjects will be divided into four groups based on the inclusion and exclusion criteria.
- GROUP I: 60 healthy subjects ( No generalised periodontitis and no CAD)
- GROUP II: 60 generalised periodontitis subjects without CAD
- GROUP III: 60 CAD subjects without generalised periodontitis
- GROUP IV: 60 subjects with Generalised periodontitis and CAD
Sub-gingival plaque samples will be collected from the subjects of all the four groups. Coronary artery plaque samples will be collected from the patients who were indicated for coronary artery bypass graft surgery (CABG) among group III and group IV.
The demographic variables , periodontal parameters , cardiac parameters , expression of periodontal viruses and inflammatory biomarkers will be measured in all four groups ,
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients willing to participate in the study.
- •Patients with 30 to 65 years of age group
- •Both genders
- •Patients should have minimum of 10 natural teeth.
- •In case of group III and IV patients with coronary heart disease to be included.
- •Exclusion Criteria
- •Patients who had undergone periodontal therapy within the previous 6 months.
- •Type I and II Diabetes mellitus
- •Sarcoidosis patients.
- •Carcinoma patients.
- •Rheumatic arthritis patients.
- •Tuberculosis patients.
- •Immunosuppressive conditions.
- •Patients with other inflammatory diseases.
排除标准
- 未提供
结局指标
主要结局
Periodontal Virus and Inflammatory Markers expression in periodontitis patients with coronary artery disease
时间窗: 2 years
Expression of EBV, CMV, HSV, Pentraxins, TLR 2 and TLR 4 using PCR
次要结局
未报告次要终点
研究者
Dr.Jaideep Mahendra
Professor and Director of PG studies
Meenakshi Ammal Dental College and Hospital