Effects of curcumin extract in beta-thalassemia/Hb E patients
Phase 2
Completed
- Conditions
- Beta-thalassemia/Hb E
- Registration Number
- TCTR20200731003
- Lead Sponsor
- Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
(1) Beta-thalassemia/Hb E
(2) Hemoglobin concentration 5-9 g/dl and serum ferritin level >= 600 ng/ml
Exclusion Criteria
(1) Lactation or pregnancy
(2) Receiving blood transfusion within three months prior to the enrollment
(3) Receiving medications for thalassemia apart from folic acid during one month before the enrollment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Iron parameters Baseline, week 24th of intervention Automated chemistry analyzer/ELISA ,Inflammatory parameters Baseline, week 24th of intervention Particle enhanced immunoturbidimetry/Multiplex cytokine assay,Oxidative stress parameters Baseline, week 24th of intervention Thiobarbituric acid assay/Flow cytometry
- Secondary Outcome Measures
Name Time Method iver and renal function tests Baseline, week 24th of intervention Automated chemistry analyzer,Hemoglobin concentration Baseline, week 24th of intervention Automated hematology analyzer ,D-dimer Baseline, week 24th of intervention Two-step enzyme immunoassay sandwich method