Does gut bacterial material pass to the bloodstream of women with Crohn's disease more easily compared with healthy women?

Not Applicable

Completed

• Conditions: Crohn's disease; gut permeability in health and Crohn's disease; Oral and Gastrointestinal - Crohn's disease

• Registration Number: ACTRN12615000518561
• Lead Sponsor: Massey University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-05-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 45

Inclusion Criteria

for Crohn's disease group
- Diagnosis of Crohn’s disease at least 6 months prior to the study
- either being in remission or having mild and moderate disease activity as assessed by the Harvey-Bradshaw Index (HBI) (remission: HBI <5, moderate disease activity: HBI 5-8, mild disease activity: HBI 8-16)

Exclusion Criteria

- Have any dietary excesses or particularities e.g. food allergies
- Drink more than one alcoholic standard drink per day (or more than seven alcoholic standard drinks per week)
- Are pregnant or lactating
- Are taking vitamin/ mineral supplements
- Have a history of diabetes, renal (kidney) disorders or cancer
- Have an aversion to venepuncture, difficult veins, a history of bleeding disorders or on anticoagulant therapy
- recent consumption of foods containing lactulose or mannitol

additional exclusion criteria for healthy volunteers:
- Have a medical or family history of Crohn’s disease, ulcerative colitis or irritable bowel disease
- Have a recent history of abdominal pain, nausea, vomiting, diarrhoea, passage of blood and mucus in stool

Study & Design

• Study Type: Observational
• Study Design: Not specified