Comparison of hyperbaric solutions of Bupivacaine, Levobupivacaine and Ropivacaine in Spinal anaesthesia for elective surgery: A prospective, Randomised, double-blind study

We are comparing bupivacaine with ropivacaine and levobupivacaine with the aim of studying clinical efficacy of hyperbaric bupivacaine, levobupivacaine and ropivacaine with respect to sensory and motor block characteristics, haemodynamic parameters and adverse effects.

Seventy five patients satisfying the inclusion and exclusion criteria undergoing elective lower limb and lower abdominal surgeries will be  enrolled in our study after obtaining written informed consent.  Patients will be  randomly       allocated into 3 groups of 25 each, receiving3 ml of 0.5% hyperbaric bupivacaine, levobupivacaine and ropivacaine.

All data will be  compiled in a case record form. Data will be analysed using SPSS v21. Chi square test will be  used as test of significance for categorical data and ANOVA test will be used as test of significance for continuous data (comparison of three groups means). Post hoc comparative analysis will be  done to determine statistical significance among the three groups. P value less than 0.05 would considered as statistically significant.

The demographic data such as age, sex, height, weight and ASA grades, operative procedures and duration of surgery would be collected.

Parameters noted in case record form will be :

• Mean Time of onset of sensory block (T8)
• Mean Time to reach peak sensory block
• Maximal sensory level was assessed;
• Time for 2 segment regressions of sensory level
• The mean Duration of sensory blockade (Tanes)
• The mean Onset time of motor blockade
• The mean Duration of Motor Blockade
• Haemodynamic parameters like pulse rate, blood pressure, respiratory rate and saturation
• Mean arterial pressure
• The mean Time taken to Walk without support
• The mean Time taken to Void
• Perioperative adverse events