Influence of Heavy Metals Exposure on in Vitro Fertilization (IVF) Outcome
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Live birth rate ("take-home baby")
研究概览
简要总结
Exposure to heavy metals may interfere with basic cellular functions, including DNA synthesis.
The aim of the study is to correlate heavy metals concentration in body fluids of reproductive importance and IVF outcome.
详细描述
Concentration of heavy metals will be measured in blood, urine, semen fluid and follicular fluid of IVF patients.
Study group: poor prognosis patients: repeated IVF failure, implantation failure, poor ovarian response, low sperm quality (according to WHO criteria) Control group: Good prognosis patients. Normal sperm count. Heavy metals concentrations will be measured using atomic absorption spectrometer, and will be correlated with IVF outcomes: number of mature oocytes obtained, fertilizations, embryos quality, and reproductive outcome post embryo transfer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Alcohol/drug abuse
- •Long-term/chronic medications
- •Severe health/mental problems
- •Dental or other transplants
- •Fragile X mutations
- •Fertility preservation
结局指标
主要结局
Live birth rate ("take-home baby")
时间窗: 9 months from embryo transfer
IVF cycle resulting in pregnancy that ends in a live birth.
次要结局
- Clinical pregnancy rate(1 month from embryo transfer)
研究者
Shahar Kol MD
Director IVF Unit, principal investigator, Assistant clinical Professor
Rambam Health Care Campus