evobupivacaine with nalbuphine and levobupivacaine with buprenorphine for spinal anaesthesia in abdominal surgeries

Phase 4

Completed

Conditions: Health Condition 1: K409- Unilateral inguinal hernia, without obstruction or gangrene

Registration Number: CTRI/2019/11/022105

Lead Sponsor: niversity College of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Patients belonging to ASA grade I or II, between 18-65 years of age, and height 150-180 cm, about to undergo elective lower abdominal surgeries under subarachnoid block will be included in the study.

Exclusion Criteria

Patients who do not give consent for subarachnoid block.

Patients with contraindications to subarachnoid block: infection at injection site, coagulopathy, space occupying lesion, increased intracranial tension, k/c/o seizure disorder, pre-existing neurological deficit, any spine deformity.

Known case of hepatic and renal disease.

On anti-arrhythmics.

Drug addicts and chronic alcoholic.

Hypersensitivity to any drugs used in the study.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Analgesic efficacy: Duration of effective analgesia (Time from the subarachnoid block to the time of patientÃ¢â?¬â?¢s first complaint of pain and VAS Ã¢â?°Â¥ 3).Timepoint: 0, 30, 60, 90 min postoperatively

Secondary Outcome Measures

Name	Time	Method
Sensory block characteristics: Onset of sensory block, maximum height of sensory block, time to achieve maximum height of sensory block, time to two segment regression of sensory block. <br/ ><br>Motor block characteristics: Maximum motor block achieved, time to achieve maximum motor block, motor block at the time of rescue analgesia. <br/ ><br>Hemodynamic changes. <br/ ><br>Sedation score. <br/ ><br>Side effects like nausea, vomiting, pruritus, shivering, urinary retention and any other <br/ ><br>Timepoint: 0, 5, 10, 15, 20, 25, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, 240, 270 300 min