Corneal Densitometry Changes With Adenoviral SEI

Completed

• Conditions: Corneal Disease
• Interventions: Drug: Tacrolimus ointment; Procedure: phototherapeutic keratectomy

• Registration Number: NCT04267991
• Lead Sponsor: Benha University

Brief Summary

Adenoviral Sub epithelial infiltrates (SEI) affect ocular function.They lead to reduced vision, photophobia, glare, halos, and foreign body sensation.

Detailed Description

first group of patients were treated with 0.03 % tacrolimus ointment twice daily for 6 months.S econd group underwent transepithelial PTK for subepithelial infiltrates. Baseline and post-treatment full ophthalmic examination was done.

Study Timeline

• Study Start: 2018-04-01
• Study First Submitted: 2020-02-11
• Study First Submitted QC: 2020-02-11
• Study First Posted: 2020-02-13
• Primary Completion: 2020-04-01
• Study Completion: 2020-04-15
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-28
• Last Update Posted: 2020-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

• adenoviral SEI

Exclusion Criteria

• Other corneal diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Tacrolimus	Tacrolimus ointment	Patients were treated with 0.03 % tacrolimus ointment twice daily for 6 months.
Phototherapeutic Keratectomy	phototherapeutic keratectomy	Patients underwent transepithelial PTK for subepithelial infiltrates.

Primary Outcome Measures

Name	Time	Method
changes of corneal densitometry	6 months	Sub epithelial infiltrates was examined with the densitometry programme of the Pentacam (Fa. Oculus,Weimar, Germany)

Trial Locations

Locations (1)

INMC; 🇦🇪 Abu Dhabi, United Arab Emirates