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Clinical Trials/NCT03156049
NCT03156049
Completed
Not Applicable

Sphenopalatine Ganglion Block Versus Occiptal Nerve Block in Treatment of Postduarl Puncture Headache

Assiut University1 site in 1 country93 target enrollmentJuly 14, 2017
ConditionsHeadache

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Headache
Sponsor
Assiut University
Enrollment
93
Locations
1
Primary Endpoint
Numeric rating pain score
Status
Completed
Last Updated
5 years ago

Overview

Brief Summary

Postdural puncture headache (PDPH) is a common complication associated with neuraxial anesthesia and diagnostic lumbar puncture (LP). PDPH is defined as a bilateral headache that develops within 7 days and disappears within 14 days after the dural puncture with a distinct postural quality. PDPH causes significant short-term disability, prevents ambulation and care of the newborn (in obstetrics), and results in a prolonged hospital stay.

Detailed Description

The sphenopalatine ganglion (SPG) is an extra-cranial neural structure located in the pterygopalatine fossa that has both sympathetic and parasympathetic components as well as somatic sensory roots. The trans-nasal approach is a low risk, noninvasive technique that is easily performed and could potentially be beneficial in the treatment of PDPH through blocking the parasympathetic flow to the cerebral vasculature through the sphenopalatine ganglion which will allow the cerebral vessels to return to normal diameter and thus relieve the headache. The greater occipital nerve contains sensory fibers from C2 and C3 segments of medulla spinals. It arises from the dorsal ramus of C2 segment, contains a thin branch from C3 segment, and innerves the medial aspect of posterior scalp up to the anterior aspect of vertex. Greater occipital nerve block (GONB) inhibits the pain sensation of this region. There is some evidence to suggest the effectiveness of GONB in the management of PDPH. Nowadays, guidelines for the management of PDPH were modified and included GONB as a part of standard management of PDPH. * Dexamethasone possess potent antiinflammatory and immunosuppressive actions by inhibiting cytokine-mediated pathways. * Many providers believe that the local anesthetic produces the rapid onset of headache relief, like an abortive agent, and that the locally acting steroid produces the preventive like action of up to 6 weeks.

Registry
clinicaltrials.gov
Start Date
July 14, 2017
End Date
June 21, 2019
Last Updated
5 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Hala Saad Abdel-Ghaffar

Assisstant professor in anesthesia and intensive care, Faculty of medicine, Assiut university, Egypt.

Assiut University

Eligibility Criteria

Inclusion Criteria

  • ASA I-II Patients undergoing elective cesarean section requiring spinal anesthesia, who developed PDPH during hospitalization or within days of the intrathecal block.

Exclusion Criteria

  • Patient refusal.
  • Any contraindication to regional block (coagulopathy or anticoagulant therapy).
  • Local scalp infection.
  • Nasal polyp, trauma, septal deviation or any nasal pathology.
  • Allergy to local anesthetics.
  • Pregnancy induced hypertension.
  • History of major psychiatric disorders.
  • Chronic headache.
  • Substance abuse.
  • Current opioid use.

Outcomes

Primary Outcomes

Numeric rating pain score

Time Frame: from intervention up to 24 hours

pain score

Secondary Outcomes

  • Numeric rating pain score for headache.(from intervention up to 24 hours)
  • Analgesic consumption(from intervention up to 24 hours)

Study Sites (1)

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