Two Patterns of Micropulse Laser in the Treatment of Chronic Central Serous Chorioretinopathy

Not Applicable

Not yet recruiting

• Conditions: Central Serous Chorioretinopathy
• Interventions: Procedure: 200μm laser spot diameter micropulse laser; Procedure: 100μm laser spot diameter micropulse laser

• Registration Number: NCT05687422
• Lead Sponsor: Beijing Hospital

Brief Summary

Central serous chorioretinopathy (CSC) is a common eye disease mainly involving the macular area, causing central visual acuity loss. Recently, subthreshold micropulse laser used in treating chronic CSC is proved to be safe and effective. However, some studies indicate that it's less effective than half dose photodynamic therapy (PDT). Certain physicians, including us, think that this may be related to micropulse laser parameters. Thus we need to explore better laser patterns to replace PDT in treating chronic CSC. The aim of this study is to compare the treatment effect of two different patterns of laser parameters (small and regular spot diameter) in treating chronic CSC. In this randomized, double blinded, controlled trial, by comparing the subretinal fluid regression ratio, central retinal thickness, macular microvisual field, macular vascular density, chroidal volume changes and visual acuity of two groups 6 months after micropulse laser treatment, we aim to evaluate the safety and efficacy of refined micropulse laser in treating chronic CSC.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-12-25
• Status Verified: 2023-01
• Study First Submitted QC: 2023-01-13
• Last Update Submitted: 2023-01-13
• Study First Posted: 2023-01-18
• Last Update Posted: 2023-01-18
• Study Start: 2023-02-01
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients age range 18-50 years
• Patients diagnosed with chronic Central serous chorioretinopathy
• Patients have signed informed consent

Exclusion Criteria

• A history of other fundus diseases or refractive media opacity
• Patients have underwent other treatment methods for chronic Central serous chorioretinopathy
• Diopter>-6D
• A history of system diseases such as hypertension or diabetes
• A history of using local or systemic corticosteroids

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
200μm laser spot diameter group	200μm laser spot diameter micropulse laser	-
100μm laser spot diameter group	100μm laser spot diameter micropulse laser	-

Primary Outcome Measures

Name	Time	Method
Subretinal fluid regression ratio	6 months	Comparing the subretinal fluid regression ratio of two groups at 6 months follow-up
Central retinal thickness changes	6 months	Comparing the central retinal thickness changes of two groups at 6 months