Glycemic Responses and of the Autonomic Cardiac Function in Diabetes Type-2 Women Post Resistance Exercise of Different Intensities
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 主要终点
- Concentration of glucose and hyperglycemia prevalence
研究概览
简要总结
The aim of this study was to investigate and correlate the glucose responses and VFC 24 hours after resistance exercise (RE) sessions at different intensities in women with type 2 diabetes (DM-2). Twelve women with DM-2 were invited to perform by one week in randomized order, two weeks interventions with experimental sessions: Session Control (CONT) without conducting RE, RE session (40% or 80% of one maximum repetition - 1RM) on day 2 and day 3 was observed the effect of the length of RE session by 11h. After that, initiated the experimental sessions, where after each of the analysis of glucose 24h by continuous monitoring system of glucose was performed, considering breakfast, lunch, dinner and sleep, and analysis performed of the RR series by a period of 48h. During control sessions, the subjects were seated comfortably for 40min and RE sessions, 40%1RM and 80%1RM, were performed in medium circuit 3 sets with 16 and 8 replications and recovery range between 60 exercises and 90seg , respectively, and between the circuits 120sec. It was observed that the concentration of glucose in the period of 24h after the session has been reduced to 40% 1RM vs. CONT and 80%1RM. Hyperglycemia was prevalent in the period 34h of the sessions CONT and 80%1RM, respectively , being different from the session 40%1RM. In postprandial times, shorter hyperglycemia was found in the session to 40% 1RM vs. CONT and 80% 1RM after breakfast, lunch and dinner. At the time of sleep, less time in hyperglycemia was found between sessions of 40% 1RM vs. 80% 1RM. Significant correlations (p <0.01) were found between glucose 24h with cardiac autonomic RRi variables, HF, LF and reason LF:HF.
详细描述
This study was a randomized cross-by blocks in accordance with CONSORT (Schulz et al., 2010).
In total, 12 women with DM-2, between 48 and 60 years old participated in the study, where they were informed of risks, benefits and objectives of the study and signed a consent form Clarified (IC) previously approved by the Ethics Committee and Ethics in Research and Studies (CEDEP) of the Federal University of São Francisco Valley (UNIVASF), Petrolina - PE, Brazil (No. 0005/180814 CEDEP).
Of the participants, 11 were taking oral hypoglycemic medication (metformin [n = 7], Sulphonylurea [n = 1] Metformin in combination with sulfonylurea [n = 3]) and performed only dietary control.
Before the first visit to the UNIVASF Exercise Physiology Laboratory, the participants underwent a resting ECG examination, which could only be submitted to the test of a one maximum repetition (1RM) and meetings after report of normality certified by cardiologist.
On the first visit to the lab, participants responded history about health history, physical activity level and risk stratification. Subsequently were performed anthropometric measurements of waist circumference, abdomen and hip, as well as height and body mass for subsequent calculation of body mass index.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 60 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Being female, diagnosed with type 2 diabetes (DM-2) and be clinically stable, and be aged between 40 and 60 years.
排除标准
- •Make use of exogenous insulin
- •Have morbid obesity (BMI> 40 kg / m2)
- •Provide uncompensated glucose and abnormalities in the electrocardiogram (ECG) at rest with suggestion of cardiac ischemia from above or below unevenness in the ST segment> 2mm or reversal in T wave
- •Presenting heart disease
- •Proliferative diabetic retinopathy
- •Severe autonomic neuropathy
- •Any limb amputation
- •Uncontrolled hypertension (systolic> 160 mmHg and / or diastolic BP> 100 mmHg)
- •Diabetic nephropathy (albuminuria ≥ 14mg / L or> 30mg / 24h) chronic renal failure (SBD, 2014; ADA, 2014)
- •Osteo-myo-articular problems that limited the exercises and being a smoker.
结局指标
主要结局
Concentration of glucose and hyperglycemia prevalence
时间窗: 24 hours
Acute bout of resistance exercise at 40% 1RM (low intensity) reduced glucose concentrations and the prevalence of hyperglycemia in 73.1 ± 37.7% and 68.4 ± 51.1% compared to the sessions CONT40% and resistance exercise 80% 1RM (high intensity) respectively in 24h from each session.
次要结局
- Heart Rate Variability(24 hours)
- Correlation between heart rate variability and glucose 24 hours(24 hours)
研究者
LOUMAÍRA CARVALHO DA CRUZ
Principal Investigator
Universidade Federal do vale do São Francisco
