Structure and Function of Salivary Proteins

• Conditions: Cystic Fibrosis

• Registration Number: NCT00916682
• Lead Sponsor: Boston Children's Hospital

Brief Summary

This study seeks to provide point-of-care clinical diagnostic systems for the diagnosis of current disease status using saliva as a sample specimen.

Detailed Description

The overall hypothesis of this study is that whole saliva and its components, due to its direct anatomic relation to the airways, provides a window on the composition and nature of the disease-specific response in the bronchial, sinus, and nasal airways. By examining proteins created in saliva, we hope to validate that saliva is an important diagnostic tool for for rapid analysis of respiratory status. We further propose that rapid salivary diagnostics will improve patient care in prevalent respiratory diseases with frequent health care utilization and high morbidity, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF).

Study Timeline

• Study Start: 2007-11
• Status Verified: 2009-06
• Study First Submitted: 2009-06-05
• Study First Submitted QC: 2009-06-08
• Last Update Submitted: 2009-06-08
• Study First Posted: 2009-06-09
• Last Update Posted: 2009-06-09
• Primary Completion: 2010-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• 6 or more years of age
• confirmed Cystic Fibrosis

Exclusion Criteria

• Pregnant

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Children's Hosptital, Boston; 🇺🇸 Boston, Massachusetts, United States