Pathophysiology of the complex regional pain Syndrom (CRPS) and effect of an innovative therapeutic approach
- Conditions
- Healthy volunteersG90Disorders of autonomic nervous system
- Registration Number
- DRKS00017214
- Lead Sponsor
- Dr. med. Sebastian Strauß, Klinik u. Poliklinik für Neurologie u. Institut für DiagnostischeRadiologie der Universität Greifswald
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Diagnosis of CRPS (Budapest criteria) in chrionic stadium (>6months) in an upper limb
Exclusion Criteria
severe mental disorder
abuse of drugs
severe paresis of the affected Hand
nerve damage at affected hand
contraindications for TMS and fMRI:
-Epilepsia, metallic implants, pacemaker,
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain intensity (visual analogue scale, after the 6 weeks training period)
- Secondary Outcome Measures
Name Time Method Activation in areas processing discriminatory aspects of pain -fMRI<br><br>Activity in the right intraparieltal sulcus (ISP), primary sensorimotor cortex contralateral to the affected hand, subcortical structures (putamen, ncl subthalamicus, ncl accumbens, thalamus), left lateral orbitofrontal sulcus during a mental rotation fMRI-task<br><br><br>Association between finger-representation (fmRI) and sensory-motor function at affected side<br><br>Intracortical inhibition at affected Hemisphere (TMS)<br><br>sensory threshold (Freyhair-filamente), spatial tactil resolution (Domes), two-point discrimination threshold (wheel-discriminator) at fingertips of both hands<br><br>Daily-use of the affected Hand (Accelerometer)<br><br>self-reported usage of the hand (Dash-questionaire)<br><br>