Effects of Add-On Treatment with Hydroxychloroquine on Glucose Fluctuations in Indian Type 2 Diabetes Patients Receiving Insulin with other oral therapy.

Dr Arjun Baidya0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•patients who are admitted to private hospital for hyperglycemia and during their hospitalization has achieved target glycemic control (7-9%) with Insulin and other oral therapy (Which include metformin, sulphonylureas, glinides, thiazolidine, DPP4i and alpha-glucosidase inhibitors).
•Treatment with insulin therapy, including once-daily basal insulin, twice-daily premixed insulin therapy, or multiple daily insulin therapy, for at least 2 weeks. Daily insulin dosage <= 60 Units per day.
•Patients with ideal body weight > 60 kg Compliance
•Patient able to understand and willing to fully comply with study procedures and restrictions.
•Patients ready to undergo a follow-up period of 9 days.

•Patients with a history of any retinopathy of any grade including diabetic retinopathy, evidence of an imminent need for retinal laser therapy, uncorrected visual acuity <20/100, abnormal visual fields, difficulty to examine optic disc, or evidence of retinal pigment epithelial abnormalities and patients with history or risk of macular edema.
•Patients with history of myalgia, aplastic anemia or agranulocytosis, granulocytopenia, psoriasis, porphyria, rash, scaling, scaling eczema, and G6PD deficiency.
•Patients with significant cardiovascular illness limiting participation of patient in a clinical trial
•Patients with abnormal renal function (Serum Cr >1.5 mg/dL, BUN > 20 mg/dL).
•Patients with abnormal liver function (AST and ALT, total bilirubin or alkaline phosphatase > 2.5 times the upper limit of normal values).
•Patients with dementia or other cognitive impairment prohibiting informed consent.
•Patients with disease of blood or haematopoetic organs
•Patients with known history of HIV 1 or HIV 2, Hepatitis B or C Viruses or syphilis infection or malignancy.
•Pregnant or lactating women
•Women of childbearing potential not practicing contraception

发起方

Dr Arjun Baidya