Exploration of Cerebral Pathophysiology During and After CABG Using CPB

Completed

• Conditions: Ischemic Heart Disease

• Registration Number: NCT02941380
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

Purpose:

The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.

Detailed Description

Postoperative cognitive decline is a well-known and well-described complication following coronary artery bypass grafting. Severity ranges from postoperative delirium to stroke, but the majority of patients with postoperative cognitive decline following coronary artery bypass grafting have decline in recent and remote memory in particular.

The reason for the cognitive decline is still not fully understood though many reasons have been proposed.

Inflammation and oxidative stress may contribute to the postoperative cognitive dysfunction which may also be in combination with a reduced cerebral autoregulation.

Study Timeline

• Study Start: 2011-07
• Primary Completion: 2012-01
• Study Completion: 2012-02
• Study First Submitted: 2016-04-29
• Status Verified: 2016-10
• Study First Submitted QC: 2016-10-20
• Last Update Submitted: 2016-10-20
• Study First Posted: 2016-10-21
• Last Update Posted: 2016-10-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Patients with ischemic heart disease admitted for coronary artery bypass grafting with the use of cardiopulmonary bypass

Exclusion Criteria

• Cerebrovascular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebral autoregulation	6 hours post operation	Flow measurement of middle cerebral artery and measurement of middel arterial pressure

Secondary Outcome Measures

Name	Time	Method
Postoperative cognitive function	One day prior to operation and three days after operation