A phase I study of a 5-peptide vaccine with immune modulators for patients with refractory metastatic colorectal cancer
Phase 1
- Conditions
- refractory metastatic colorectal cancer
- Registration Number
- JPRN-UMIN000026163
- Lead Sponsor
- Department of Surgery, Kindai University Faculty of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Not provided
Exclusion Criteria
1)patient having double cancer 2)patient having interstitial pneumonia 3)patient having brain metastasis 4)patient having mental disorder 5)patient having uncontrollable heart disorder, pulmonary disorder or renal disorder 6)patient having bleeding tendency 7)patient having any allergic reaction to using drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The safety of the immune modulators with/without 5-peptide cocktail vaccine
- Secondary Outcome Measures
Name Time Method 1) peptide-specific CTL responses and the relationship with clinical responses 2)Overall survival and preogression-free survival