Preopioid Versus Nonopioid in Total Knee Arthroplasty (TKA)

Completed

• Conditions: Postoperative Pain

• Registration Number: NCT01323179
• Lead Sponsor: Hvidovre University Hospital

Brief Summary

Observational study evaluating pain response after total knee arthroplasty (TKA) in patients taking strong, weak or no opioids preoperatively.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-03
• Study First Submitted: 2011-03-24
• Study First Submitted QC: 2011-03-24
• Study First Posted: 2011-03-25
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-04
• Last Update Posted: 2013-06-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

Patients operated with elective, primary, unilateral total knee arthroplasty (TKA) (taking strong or weak opioid daily for minimum 4 weeks or opioid naive patients)

Exclusion Criteria

• Bilateral / revision arthroplasty
• Disease affection central or peripheral nerve function
• Alcohol and medical abuse
• Daily use of glucocorticoids
• Malignancy
• BMI > 40
• Dementia or other cognitive dysfunction
• Treatment of anxiety or depression

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain	24 hours	Pain during ambulation and at rest

Secondary Outcome Measures

Name	Time	Method
Pain	7 days	Pain during ambulation and at rest
Opioid consumption	7 days

Trial Locations

Locations (4)

Dep. of ortopedic surgery, Vejle Sygehus; 🇩🇰 Vejle, Denmark

Dep. of Anesthesiology, Hvidovre University Hospital; 🇩🇰 Copenhagen, Hvidovre, Denmark

Dep. of ortopedic surgery, Gentofte Hospital; 🇩🇰 Hellerup, Denmark

Dep. of ortopedic surgery, Regionshospitalet Holstebro; 🇩🇰 Holstebro, Denmark