NCT02595619已完成不适用
Combined Strategy of Renal Replacement Therapy Plus Extracorporeal Carbon Dioxide Removal in Patients With Acute Kidney Injury
University of Turin, Italy2 个研究点 分布在 1 个国家目标入组 14 人开始时间: 2015年12月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Achievement of tidal volume reduction to 4 mL/kg while maintaining pH and PaCO2 to ± 20% of baseline values
研究概览
简要总结
This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows reduction of tidal volume and plateau pressure. Systemic Inflammatory Response and Safety Variables will also be analysed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with acute kidney injury (AKI) requiring renal-replacement therapy and mechanical ventilation of duration ≥ 48 hours
排除标准
- •little chance of survival at 24 h (according to clinical judgment), pregnancy, mechanical ventilation with expected duration lower than 48h, age under 18 and over 90
研究组 & 干预措施
RRT plus ECCO2R
Experimental
干预措施: RRT plus ECCO2R (Device)
结局指标
主要结局
Achievement of tidal volume reduction to 4 mL/kg while maintaining pH and PaCO2 to ± 20% of baseline values
时间窗: 72 hours
次要结局
- Assessment of the changes in pH(72 hours)
- Assessment of the changes in PaO2(72 hours)
- Assessment of the changes in PaCO2(72 hours)
- Evaluation of inflammatory mediators release in plasma samples of patients(72 hours)
研究者
Vito Fanelli MD, PhD
Assistant Professor
University of Turin, Italy
研究点 (2)
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