NCT06681818招募中不适用
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
研究概览
简要总结
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient plans to have partial liver resection for primary liver pathology or metastatic disease
- •Patient is able to comprehend and willing to sign the written consent form
排除标准
- •Patients < 18 years
- •Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test
研究组 & 干预措施
all participants
Experimental
all participants will provide breath samples to detect carbon monoxide levels
干预措施: carbon monoxide measurement via smokerlyzer (Other)
结局指标
主要结局
correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
时间窗: measurements will be taken pre, then 4 hours and 24 hours post resection
patients will be asked to donate exhaled breath into a smokerlyzer device
次要结局
- level of carbon monoxide in exhaled air of patients(measurements will be taken pre, then 4 hours and 24 hours post resection)
- quantity of liver regeneration, liver volume (ml)(one and three months after resection)
- quality of hepatic regeneration, normalized liver function(one and three months post resection)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial HepatectomyLiver CancerNCT04195438University of Maryland, Baltimore25
已完成
不适用
Effects of Oxygen After Abdominal Oncological SurgeryAbdominal CancerNCT06321874Jules Bordet Institute49
Unknown
不适用
Role of Heme-oxygenase (HO) and Nitric Oxide (NO) Pathway in Patients With Obstructive Sleep Apnea (OSA) and Pulmonary Hypertension (PH)Obstructive Sleep ApneaPulmonary HypertensionNCT02368171Southern California Institute for Research and Education60
Enrolling By Invitation
不适用
Investigation of Hemoglobin Oxygenation With Third Harmonic Generation MicroscopyTumorOxygen DeficiencyHypoxiaDiabetesNCT03619356National Taiwan University Hospital100
已完成
不适用
Heme Oxygenase-1 in Liver Surgeryiver surgery/pharmacological preconditioningSurgeryLiver surgeryISRCTN94278797niversity of Edinburgh (UK)42