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Clinical Trials/NCT05523453
NCT05523453
Completed
Not Applicable

Examination and Refinement of a Novel Treatment for Posttraumatic Stress Disorder: Processing of Positive Memories Technique (PPMT)

University of North Texas, Denton, TX1 site in 1 country70 target enrollmentFebruary 23, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Stress Disorders, Post-Traumatic
Sponsor
University of North Texas, Denton, TX
Enrollment
70
Locations
1
Primary Endpoint
Posttraumatic Stress Disorder Checklist for DSM-5 scores
Status
Completed
Last Updated
7 months ago

Overview

Brief Summary

Posttraumatic stress disorder (PTSD) has devastating health consequences. Evidence-based PTSD interventions address the substantial burden of PTSD on the health of individuals and societies; however, several individuals receiving these interventions drop out and not all individuals experience improvement in PTSD symptoms. Moreover, these current PTSD interventions primarily target trauma memories. Notably, growing evidence suggests that PTSD symptoms are related to difficulties in the encoding and retrieving of positive memories as well.

Thus, the proposed study will examine effects of and targets underlying a novel PTSD technique focused on narrating and detailing positive memories - Processing of Positive Memories Technique (PPMT). Methodologically, 70 individuals will be randomly assigned to PPMT vs. Supportive Counseling (SC) for this study.

The aims of the proposed study include (1) examining PPMT's effects on PTSD symptom severity and stress systems' dysregulation (i.e., awakening salivary alpha amylase [sAA] and cortisol); (2) examining mechanisms underlying PPMT's effects; and (3) refining PPMT. It is hypothesized that the PPMT arm will report greater decreases in PTSD severity and sAA/cortisol ratios. Further, it is hypothesized that PPMT-related improved affect will mediate the association between study arm (PPMT vs. SC) and changes in PTSD severity. Lastly, feedback will be obtained from study participants on PPMT's feasibility, format, and content to refine PPMT.

The proposed study may contribute preliminary evidence on the potential significance of targeting positive memories in PTSD interventions.

Registry
clinicaltrials.gov
Start Date
February 23, 2023
End Date
February 19, 2025
Last Updated
7 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
University of North Texas, Denton, TX
Responsible Party
Principal Investigator
Principal Investigator

Ateka Contractor

Associate Professor

University of North Texas, Denton, TX

Eligibility Criteria

Inclusion Criteria

  • 18-65 years old
  • Willing/able to provide informed consent
  • Past month DSM-5 posttraumatic stress disorder (PTSD) diagnosis
  • Working knowledge of English

Exclusion Criteria

  • Active suicidal intent or attempts
  • Active psychosis
  • Currently receiving mental health therapy (past 3 months)
  • Dosage changes in psychiatric medications (past 3 months)
  • Currently pregnant

Outcomes

Primary Outcomes

Posttraumatic Stress Disorder Checklist for DSM-5 scores

Time Frame: 3-month post treatment completion

PTSD symptom severity is assessed using 20 items with response options ranging from 0 = not at all to 4 = extremely.

Secondary Outcomes

  • Saliva Samples(3 times each day for 2 consecutive days after the last therapy session)
  • Positive and Negative Affect Schedule(1 week after last therapy session)

Study Sites (1)

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