Comparison of Topical 5%Potassium Hydroxide vs Liquid Nitrogen in the Treatment of Plane Warts

Phase 1

Completed

• Conditions: Plan Warts
• Interventions: Drug: 5%potassium hydroxide; Drug: Liquid nitrogen

• Registration Number: NCT05895071
• Lead Sponsor: Combined Military Hospital Abbottabad

Brief Summary

ABSTRACT Objective: To study the efficacy while comparing Potassium hydroxide 5% with liquid nitrogen in treatment of plane warts.

Study design: Randomized-controlled trial (RCT), (Double-blind). Study setting and duration: Dept dermatology, CMH-Abbottabad, Nov-2022 / April-2023.

Methodology: The sample size of 60 patients (children and adults aged 4 to 30 years) was calculated using Openepi app sample size RCT calculator, after informed consent by using non-probability consecutive sampling technique. Patients randomly assigned into two groups i.e. In group-A 30 patients were given topical 5%-potassium hydroxide solution on affected area once at night upto 4 weeks and in group-B 30 patients treated with cotton bud method of cryotherapy with liquid nitrogen once every two weeks. Patients were reassessed at every two weeks and final assessment was done at 12th week whereas followed up for 3 months to monitor recurrence. Demographic information and frequency percentages were calculated for qualitative variables by using SPSS26. To determine statistical significance taking p-value \<0.05 as significant, and χ2-square test was used.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-01
• Primary Completion: 2023-04-30
• Study Completion: 2023-04-30
• Status Verified: 2023-05
• Study First Submitted: 2023-05-16
• Study First Submitted QC: 2023-05-30
• Last Update Submitted: 2023-05-30
• Study First Posted: 2023-06-08
• Last Update Posted: 2023-06-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age 4-30 years
• Both males and females
• Greater than 3 number of warts

Exclusion Criteria

• Pregnancy
• Breast feeding
• Those who are taking immunosupressive drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A Topical 5% potassium hydroxide	5%potassium hydroxide	In group-A 30 patients were given topical 5%-potassium hydroxide solution on affected area once at night upto 4 weeks
Group B Liquid nitrogen	Liquid nitrogen	in group-B 30 patients treated with cotton bud method of cryotherapy with liquid nitrogen once every two weeks. Patients were reassessed at every two weeks and final assessment was done at 12th week.

Primary Outcome Measures

Name	Time	Method
Comparative Efficacy of topical 5% Potassium hydroxide and liquid nitrogen in the treatment of plane warts	12 weeks	Decrease in number or size of warts

Trial Locations

Locations (1)

Sana aslam; 🇵🇰 Abbottabad, Khyber Pakhtun Khwaa, Pakistan