A Multiple-Center, Randomized, Double-Blind Study of Aripiprazole for Treatment of Methamphetamine Dependence
Overview
- Phase
- Phase 4
- Intervention
- Aripiprazole
- Conditions
- Methamphetamine Dependence
- Sponsor
- Wei Hao
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- abstinent time of Methamphetamine addict
- Status
- Terminated
- Last Updated
- 11 years ago
Overview
Brief Summary
Methamphetamine substance use is common worldwide. No approved pharmacologic treatments for methamphetamine dependence exist. Aripiprazole are Second generation antipsychotics,but have different pharmacological effects of neurotransmitters.To determine whether mirtazapine would reduce methamphetamine use among mehtamphetamine addicts.
Detailed Description
Methods:A Multiple-Center, Randomized, Double-Blind.
Investigators
Wei Hao
The Second Xiangya Hospital of Cental South University
Central South University
Eligibility Criteria
Inclusion Criteria
- •Patients,Diagnostic and Statistical Manual of Mental Disorders 4thed. (DSM-IV) criteria for Methamphetamine dependence.
- •Must sign a Information consent form.
- •Required to provide detailed address and phone number
Exclusion Criteria
- •Serious organic disease.
- •Suicide ideation or hurt others.
- •Taking antipsychotic within two weeks before.
- •drug allergy to Risperidone or Aripiprazole.
- •pregnancy and breastfeeding women.
Arms & Interventions
Aripiprazole
Aripiprazole arm,5mg/pill,10mg/day.last12weeks.
Intervention: Aripiprazole
Sugar pill
placebo arm,5mg/pill,10mg/day,last12weeks
Intervention: placebo
Outcomes
Primary Outcomes
abstinent time of Methamphetamine addict
Time Frame: up to 3 months
methamphetamine-positive urine test results,self-reports of substance use
Secondary Outcomes
- number of Participants with Adverse Events as a Measure of Safety and Tolerability(up to 3 months)