Non- Essential Amino Acid Requirements and Metabolism in Humans
- Conditions
- Healthy Adult Males
- Registration Number
- NCT02009917
- Lead Sponsor
- University of British Columbia
- Brief Summary
Protein is a major structural component of all cells in the body. The nutritional importance of protein is because of their amino acids. 9 are called essential and 11 are called non-essential, based on whether we need to get them from diet. This classification is based on studies done using older techniques. Recent studies suggest that these so called non-essential amino acids play important roles in our body's health. For the first time, this proposal defines an experimental design to examine non- essential amino acid/nitrogen requirements and metabolism in humans using the Indicator Amino Acid Oxidation (IAAO) technique.
The objective of the current study is to examine the application of IAAO technique to determine the non-essential amino acid/nitrogen requirement in adult humans.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 6
- 20-40 years of age
- Male
- Classified as normal body weight based on body mass index (BMI) 18.5-25kg/m2
- Free of any concurrent illness
- Men not in good health or have a metabolic, neurological, genetic or immune disorder including diabetes and hypertension
- Men who are classified as underweight(<18.5kg/m2), overweight(25-30kg/m2) or obese (>30kg/m2) using the BMI classification)
- Men who are allergic to milk, eggs and egg protein
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 13 Carbon dioxide production 8 hours (1study day) Urine and breath samples will be collected to measure the rate of oxidation of expired breath and flux by enrichment of urine.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Child and Family Research Institute
🇨🇦Vancouver, British Columbia, Canada