Impact of Prediabetes on Acute Coronary Syndrome

Completed

• Conditions: Diabetic Cardiomyopathy
• Interventions: Diagnostic Test: Troponin, Lipid profile, HBA1C, Fasting blood glucose level, Creatinine, Body Mass Index

• Registration Number: NCT05102851
• Lead Sponsor: Sohag University

Brief Summary

Diabetes mellitus is one of the chronic non-communicable diseases which have emerged as a leading global health problem. According to the International Diabetes Federation Atlas guideline report, currently, there are 352 million adults with impaired glucose tolerance who are at high risk of developing diabetes in the future. In 2017, it was estimated that 425 million people (20-79 years of age) suffered from Diabetes mellitus, and the number is expected to rise to 629 million by 2045. Moreover, Egypt is considered one of the top 10 countries in the world

Detailed Description

Acute Coronary Syndrome refers to a constellation of symptoms compatible with acute myocardial ischemia. The syndrome includes systolic time segment elevation myocardial infarction non-systolic time segment elevation myocardial infarction and unstable angina.

Patients have an over tenfold risk for cardiovascular disease in their lifetime. In the United States, 77% of diabetes-related hospital admissions are for cardiovascular complications. A key feature of diabetes contributing to this is the development of accelerated atherosclerosis.

Prediabetes is a collective term that encloses individuals with glucose levels lower than cutoff levels for diabetes but too high to be considered normal. Fasting blood glucose 6.1 mmol/L- \<7.0 mmol/L. In impaired glucose tolerance the ranges of blood glucose are\>7.8 mmol/L-\<11.1 mmol/L4.

Prediabetes is associated with a significant increase in cardiovascular morbidity and mortality and necessitates early and adequate intervention to prevent the development of complications, and progression to overt diabetes.

Higher fasting glucose levels in patients with the acute coronary syndrome were associated with worse clinical outcomes irrespective of the presence of diabetes mellitus. Similarly, higher fasting glucose was a marker of adverse outcomes in patients without diabetes presenting with acute systolic time segment elevation myocardial infarction.

Impaired glucose tolerance is common among non-diabetic patients admitted with the acute coronary syndrome. However, evidence is controversial regarding the prognostic impact of 'prediabetes' on the clinical outcome

Study Timeline

• Status Verified: 2021-07
• Study Start: 2021-08-01
• Study First Submitted: 2021-08-18
• Study First Submitted QC: 2021-10-20
• Study First Posted: 2021-11-02
• Primary Completion: 2022-08-01
• Study Completion: 2022-08-23
• Last Update Submitted: 2022-08-28
• Last Update Posted: 2022-08-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• All patients with acute coronary syndrome
• Diabetic patients and will be subdivided into controlled and uncontrolled Pre-diabetic patients.
• Non-diabetic patient(Controlled)

Exclusion Criteria

• Patient under 18 years old
• Pregnancy
• Chronic kidney disease
• Familiar hyperlipidemia.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patient with acute coronary syndrome	Troponin, Lipid profile, HBA1C, Fasting blood glucose level, Creatinine, Body Mass Index	All patients with the acute coronary syndrome were included in the study. Pre-diabetic patient. Non-diabetic patient(Controlled)

Primary Outcome Measures

Name	Time	Method
CCU admission	6 months	All patients admitted with acute coronary syndrome will be included in the research
Hba1c	Day 1	We consider patients with Hba1c less than 5.7% not diabetic , Patients with Hba1c from 5.7%-6.4% prediabetic and patients with Hba1c 6.5% or more diabetic patients

Trial Locations

Locations (1)

Sohag University; 🇪🇬 Sohag, Egypt