Clinical efficacy of topical fixed dose triple combination of Clindamycin Phosphate, Adapalene and Benzoyl Peroxide in acne vulgaris

This study aims to determine the efficacy of fixed dose triple combination of topical Clindamycin Phosphate 1.2%, Adapalene 0.15%, Benzoyl Peroxide 3.1 % gel in Acne Vulgaris The study will be Prospective, Open label, Single arm interventional study and will be conducted over 18 months at GMCH Chandigarh.

50 patients will be recruited in this study. Patients of acne vulgaris (Grade 1 and Grade 2) and of 12-50 years age will be included in this study. Participants will be instructed to cleanse the facial skin using non medicated gentle soap and water and subsequently apply the designated topical formulation to the affected areas at bedtime. They will be instructed to avoid applying cosmetics, moisturizers, or any other topical treatments on their face.

Clinical evaluation and photographic assessment will be done at baseline first visit and at each follow up visit (3,6,9,12 weeks). The therapeutic response will be evaluated objectively by assessing the total lesion count and calculating the percentage reduction from baseline values. Monitoring and categorization of adverse events will also be done in this study.

A triple drug combination may enhance therapeutic outcomes by acting upon multiple acne-related mechanisms simultaneously and by increasing the compliance of treatment.