Status of the growth hormone/ insulin-like growth factor-1 (GH/IGF-1) axis in relation to growth failure, body weight and neuroprotection in children with Ataxia telangiectasia (AT) - Growth hormone in AT (GHAT)

Goethe-Universität Frankfurt/Main0 个研究点开始时间: 2009年9月14日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•diagnosis of AT
•no fusion of epiphyses/closed growth plates determined by X-ray of left wrist and hand (special skeletal age film)
•age between 3 years to 18 years and no completed puberty
•growth failure: height below the 10th percentile for chronological age
•growth failure, defined as growth velocity (measured as linear growth) less than 5% to 10% of that expected for children of the same age group, over the past 12 months
•provide evidence of serum IGF-1 level performed within the preceding 6 months and the results fall below normal limits for age
•Are the trial subjects under 18? yes
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) no
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•fusion of epiphyseal plates
•age under 3 years or completion of puberty
•serum IGF-1 level that is within normal limits for age
•be above the 10th percentile height for chronological age
•history of anaphylactic reaction or hypersensitivity to one of the GH formulation
•any active or suspected neoplasia
•signs of intracranial hypertension as evidenced by papilledema

发起方

Goethe-Universität Frankfurt/Main