IRCT20180908040972N1
Recruiting
Phase 3
The Effect of Vitamins B6, B9, B12 Supplementation on Liver Enzymes, Inflammatory and Oxidative Stress Markers, Insulin Resistance, Lipid Profile and Serum Homocysteine in Overweight or Obese Patients with Nonalcoholic Fatty Liver Disease
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Shiraz University of Medical Sciences
- Enrollment
- 50
- Status
- Recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Willingness to participate in study
- •Age range from 25 to 65 years
- •Body mass index (BMI) from 25 to 40 kg /m2
- •Serum alanine aminotransferase (ALT) greater than the upper reference limit and steatosis grade \> 1 on ultrasonography
Exclusion Criteria
- •Alcohol abuse (more than 20 grams per day in women and 30 grams per day in men)
- •Acute and chronic liver diseases (all types of hepatitis? biliary disease? cirrhosis? inherited disorders affecting liver condition such as storage disease of iron, and copper? etc.)
- •Gastrointestinal diseases (gastritis, celiac, steatorrhea, crohn, colitis, gastrointestinal bypass surgery, etc.)
- •Hypertension and cardiovascular diseases
- •Renal disease, lung disease, autoimmune diseases, rheumatoid arthritis, multiple sclerosis, cancer, thyroid disorders, epilepsy, diabetes
- •All types of anemia, thalassaemia, A\-beta\-lipoproteinemia, hypoalbuminemia
- •Hereditary disorders in homocysteine metabolizing enzymes
- •Hepatotoxic drugs, gastric acid suppression drugs, antiepileptic drug and medications such as corticosteroids, contraceptive pills estrogen, progesterone, androgen, levodopa, cycloserine, phenelzine, isoniazid, penicillamine, sulfasalazine
- •Weight loss during the last 6 months
- •Follow special diet (weight loss diet, vegeterian diet, etc.)
Outcomes
Primary Outcomes
Not specified
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